Fresh analysis indicates that individuals who come off new weight-loss injections like Mounjaro or Wegovy may regain reduced body mass far faster than those who stop conventional diet and exercise plans.
Published data in a major health publication points out that while overweight people can lose substantial amounts of their total mass while on the medication, the weight returns at an estimated rate of nearly a kilo each month after stopping.
"People using these treatments need to be informed of the potential of quick weight regain when the therapy is stopped," stated lead investigator Dr. Susan Jebb.
That rate of recovery means a return to starting mass within about 18 months.
Comparing Approaches
The analysis, which reviewed 37 of studies involving thousands of patients, contrasted the effects of GLP-1 agonists with conventional dieting.
The team emphasize that individuals who shed pounds through dieting generally experience a slower creep back—around 0.1 kg a month—once they finish.
The Reason for the Quick Rebound
Doctors believe the way of the injections explains the accelerated regain.
The injections mimic a body's own chemical called glucagon-like peptide-1, which moderates hunger.
"Long-term administration of GLP-1 concentrations far above than normal could lead to the body to produce less of its own natural hormone, and could diminish responsiveness to its actions," said Dr. Adam Collins, a dietetics expert.
"Discontinuation of this medication results in hunger is uncontrolled, making binge eating a significant risk."
A Chronic Disease?
The NHS suggest the jabs for people with obesity-related medical conditions, accompanied by recommended lifestyle changes.
Professionals contend that, considering the significant potential of relapse, the therapy might need to be ongoing.
This view is supported by drug manufacturers, who note that the results "emphasize the chronic character of obesity," comparing it to managing diseases like diabetes.
Patient Testimonies
People who have discontinued the jabs explain a intense resurgence of cravings.
"It was like a switch flipping and you're instantly starving," described a patient.
This challenge is compounded if individuals have not adopted permanent dietary or behavioural modifications during therapy.
Growing Adoption
Figures show that a significant number of adults in the UK have used these injections in the past year, with desire remaining high.
- Adoption is greater among females compared to men.
- The 40s and 50s demographic shows the highest usage rates.
- Many access the drugs through private prescriptions rather than public health services.
In conclusion, clinicians caution that while these medications are potent agents for shedding pounds, they are not a magic cure and long-term success likely depends on ongoing behavioural support.
